Jung, Su Yon and Mancuso, Nicholas and Han, Sihao and Zhang, Zuo-Feng (2020) The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study. Frontiers in Genetics, 11. ISSN 1664-8021
![[thumbnail of pubmed-zip/versions/1/package-entries/fgene-11-540724/fgene-11-540724.pdf]](http://libra.article2submit.com/style/images/fileicons/text.png)
Text
pubmed-zip/versions/1/package-entries/fgene-11-540724/fgene-11-540724.pdf - Published Version
Download (422kB)
Abstract
Background: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive.
Methods: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women.
Results: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed.
Conclusion: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer.
| Item Type: | Article |
|---|---|
| Subjects: | Archive Paper Guardians > Medical Science |
| Depositing User: | Unnamed user with email support@archive.paperguardians.com |
| Date Deposited: | 18 Feb 2023 13:01 |
| Last Modified: | 04 Jul 2025 03:37 |
| URI: | http://libra.article2submit.com/id/eprint/87 |
Actions (login required)
- View Item